Fudan University Cancer Center Acquiring Invasiveness Primary carcinoma cell(s)must Disengage from their neighboring epithelial cells ● Become moti|e Degrade the surrounding extracellular matrix epithelium Basement OTOYOTO membrane Normal epithelium Loss of epithelial polarity Epithelial cells become and multilayering of increasingly motile, upregulate epithelium protease activity, degrade basement mem brane and invade dapted from Saha and Marshall Nat Rev Cancer 200 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Acquiring Invasiveness Primary carcinoma cell(s) must: •Disengage from their neighboring epithelial cells •Become motile •Degrade the surrounding extracellular matrix