Fudan University Cancer Center Invasion and Metastasis cancer cells proliferate and spread (metastasize to Blood Vessel other parts of the body Cancer cells invade Invasion-direct migration surrounding tissues and and penetration into 2 vessels neighboring tissues Cancer cells are transported by the circulatory system Metastasis -cancer cell to distant sites penetrate into lymphatic Cancer cells reinvade and system and blood vessels grow at new location 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Invasion and Metastasis • cancer cells proliferate and spread (metastasize) to other parts of the body • Invasion - direct migration and penetration into neighboring tissues • Metastasis - cancer cells penetrate into lymphatic system and blood vessels