10 Fungal immunomodulatory proteins Adenocarcinoma Cell Line.Molecular Carcinogenesis Murasugi,A.,Tanaka,S.,Komiyama,N.,Iwata,N.,Kino,K., 45:220-229 Tsunoo,H.and Sakuma,S.(1991).Molecular Cloning of a cDNA and a Gene Encoding an Immunomodulatory Protein, Lin,J.P,Bai,J.Y.and Li,Y.F.(2006).Structure and Function LingZhi-8,from a Fungus,Ganoderma lucidum.Analytical Study of Fungal Immunomodulatory Protein (FIP).Journal and Bioanalytical Chemistry 266:2486-2493. of Liaoning Normal University (Natural Science Edition)29: 84-87.(In Chinese with English abstract). Paaventhan,P.,Joseph,J.S.,Seow,S.V.,Vaday,S.,Robinson, H.,Chua,K.Y.and Kolatkar,P.R.(2003).A 1.7A Structure Lin,J.W.(2009).Expression and Bioactivity Study of of Fve,a Member of the New Fungal Immunomodulatory Recombinant Fungal Immunomodulatory Protein(FIP)in Protein Family.Journal of Molecular Biology 332:461-470. Pichia Pastoris GS115.Dissertation,Northeast Normal University.Changchun,China. Rincon,M.,Enslen,H.,Raingeaud,J.,Recht,M.,Zapton, T.,Su,M.S.,Penix,L.A.,Davis,R.J.and Flavell,R.A.(1998). Lin,J.W.,Hao,L.X.,Xu,G.X.,Sun,F.,Gao,E,Zhang,R. Interferon-y Expression by ThI Effector T Cells Mediated and Liu,L.X.(2009).Molecular Cloning and Recombinant By the p38 MAP Kinase Signaling Pathway.The EMBO Expression of a Gene Encoding a Fungal fournal17:2817-2829. Immunomodulatory Protein from Ganoderma lucidum in Pichia pastoris.World Journal of Microbiology and Singh,R.S.,Bhari,R.and Kaur,H.P.(2010).Mushroom Biotechnology 25:383-390. Lectins:Current Status and Future Perspectives.Critical Reviews in Biotechnology 30:99-126. Lin,J.Y.,Wu,H.L.and Shi,G.Y.(1975).Toxicity of the Cardiotoxic Protein Flammutoxin,Isolate from Edible Song,L.Y,Yu,Q.and Pu,E.R.(2003).The Study Progress Mushroom Flammulina velutipes.Toxicon 13:323-331. on Expression System of Some Important Yeast.Chinese Journal of Blood Transfusion 16:209-211.(In Chinese). Lin,W.H.,Hung,C.H,Hsu,C.I.and Lin,J.Y.(1997). Dimerization of The N-terminal Amphipathic Alpha-helix Sun,Z.X.and Wang,R.X.(2009).Present Status and Future Domain of The Fungal Immunomodulatory Protein from Prospects of Bioactive Proteins from Edible Fungi.Acta Edulis Ganoderma tsugae (Fip-gts)Defined by a Yeast Two-Hybrid Fungi 12:85-90.(in Chinese with English abstract). System and Site-Directed Mutagenesis.The Journal of Biological Chemistry 272:20044-20048. Tsai,L.L.(2007).Immunomodulatory protein cloned from Ganoderma microsporum.Patent.US Lin,Y.L.,Liang,Y.C.,Tseng,Y.S.,Huang,H.Y.,Chou,S.Y., 7601808B2. Hseu,R.S.,Huang,C.T.and Chiang,B.L.(2009).An Immunomodulatory Protein,Ling Zhi-8,Induced Activation Wang,P.H.,Hsu,C.I.,Tang,S.C.,Huang,Y.L.,Lin,J.Y.and and Maturation of Human Monocyte-Derived Dendritic Cells Ko,J.L.(2004).Fungal Immunomodulatory Protein from by the NF-KB and MAPK Pathways.Journal of Leukocyte Flammulina velutipes Induces Interferon-Y Production Bi0logy86:877-889. Through p38 Mitogen-Activated Protein Kinase Signaling Pathway.Agricultural and Food Chemistry 52:2721-2725. Liu,Y.,Guo,L.Q.,Wang,H.Y.and Lin,J.F.(2006).Isolation and Sequence Analysis of Immunomodulatory Protein Gene Wang,X.L.,Liang,C.Y.,Li,H.R.,Li,B.Z.and Sun,F.(2010). from Ganoderma.Chinese Journal of Tropical Crops 27:54- Recombinant Ganoderma lucidum Immunoregulatory Protein 58.(in Chinese with English abstract). (rLZ-8)Induces Nuclear-Stress Apoptosis in K562 Cells. Cellular Molecular Immunology 26:616-623. Liu,Z.T.and Luo,X.C.(2002)Application and biotechnology on Edulis Fungi,(Bei Jing,Bei Jing:Tsinghua Wasser,S.P.(2002).Medicinal Mushrooms as a Source of University Press Ltd.(in Chinese). Antitumor and Immunomodulating Polysaccharides.Applied Microbiology and Biotechnology 60:258-274. Lull,C.,Wichers,H.J.and Savelkoul,H.F.(2005).Anti- inflammatory and Immunomodulating Properties of Fungal Wasser,S.P.(2011).Current Findings,Future Trends,and Metabolites.Mediators Inflammation 2:63-80. Unsolved Problems in Studies of Medicinal Mushrooms. Applied Microbiology and Biotechnology 89:1323-1332. Moradali,M.F,Mostafavi,H.,Ghods,S.and Hedjaroude, G.A.(2007).Immunomodulating and Anticancer Agents in Wichers,H.(2009).Immunomodulation by Food:Promising the Realm of Macromycetes Fungi (Macrofungi). Concept for Mitigating Allergic Disease?Analytical and International Immunopharmacology 7 701-724. Bioanalytical Chemistry 395:37-45.10 Fungal immunomodulatory proteins Adenocarcinoma Cell Line. Molecular Carcinogenesis 45:220-229. Lin, J.P., Bai, J.Y. and Li, Y.F. (2006). Structure and Function Study of Fungal Immunomodulatory Protein (FIP). Journal of Liaoning Normal University (Natural Science Edition) 29: 84-87. (In Chinese with English abstract). Lin, J.W. (2009). Expression and Bioactivity Study of Recombinant Fungal Immunomodulatory Protein (FIP) in Pichia Pastoris GS115. Dissertation, Northeast Normal University. Changchun, China. Lin, J.W., Hao, L.X., Xu, G.X., Sun, F., Gao, F., Zhang, R. and Liu, L.X. (2009). Molecular Cloning and Recombinant Expression of a Gene Encoding a Fungal Immunomodulatory Protein from Ganoderma lucidum in Pichia pastoris. World Journal of Microbiology and Biotechnology 25:383-390. Lin, J.Y., Wu, H.L. and Shi, G.Y. (1975). Toxicity of the Cardiotoxic Protein Flammutoxin, Isolate from Edible Mushroom Flammulina velutipes. Toxicon 13:323-331. Lin, W.H., Hung, C.H, Hsu, C.I. and Lin, J.Y. (1997). Dimerization of The N-terminal Amphipathic Alpha-helix Domain of The Fungal Immunomodulatory Protein from Ganoderma tsugae (Fip-gts) Defined by a Yeast Two-Hybrid System and Site-Directed Mutagenesis. The Journal of Biological Chemistry 272: 20044-20048. Lin, Y.L., Liang, Y.C., Tseng, Y.S., Huang, H.Y., Chou, S.Y., Hseu, R.S., Huang, C.T. and Chiang, B.L. (2009). An Immunomodulatory Protein, Ling Zhi-8, Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells by the NF- κB and MAPK Pathways. Journal of Leukocyte Biology 86:877-889. Liu, Y., Guo, L.Q., Wang, H.Y. and Lin, J.F. (2006). Isolation and Sequence Analysis of Immunomodulatory Protein Gene from Ganoderma. Chinese Journal of Tropical Crops 27:54- 58. (in Chinese with English abstract). Liu, Z.T. and Luo, X.C. (2002) Application and biotechnology on Edulis Fungi, (Bei Jing, Bei Jing: Tsinghua University Press Ltd. (in Chinese). Lull, C., Wichers, H.J. and Savelkoul, H.F. (2005). Anti￾inflammatory and Immunomodulating Properties of Fungal Metabolites. Mediators Inflammation 2:63-80. Moradali, M.F., Mostafavi, H., Ghods, S. and Hedjaroude, G.A. (2007). Immunomodulating and Anticancer Agents in the Realm of Macromycetes Fungi (Macrofungi). International Immunopharmacology 7 701-724. Murasugi, A., Tanaka, S., Komiyama, N., Iwata, N., Kino, K., Tsunoo, H. and Sakuma, S. (1991). Molecular Cloning of a cDNA and a Gene Encoding an Immunomodulatory Protein, LingZhi-8, from a Fungus, Ganoderma lucidum. Analytical and Bioanalytical Chemistry 266:2486-2493. Paaventhan, P., Joseph, J.S., Seow, S.V., Vaday, S., Robinson, H., Chua, K.Y. and Kolatkar, P.R. (2003). A 1.7Å Structure of Fve, a Member of the New Fungal Immunomodulatory Protein Family. Journal of Molecular Biology 332:461-470. Rincón, M., Enslen, H., Raingeaud, J., Recht, M., Zapton, T., Su, M.S., Penix, L.A., Davis, R.J. and Flavell, R.A. (1998). Interferon-γ Expression by Th1 Effector T Cells Mediated By the p38 MAP Kinase Signaling Pathway. The EMBO Journal 17:2817-2829. Singh, R.S., Bhari, R. and Kaur, H.P. (2010). Mushroom Lectins: Current Status and Future Perspectives. Critical Reviews in Biotechnology 30:99-126. Song, L.Y., Yu, Q. and Pu, F.R. (2003). The Study Progress on Expression System of Some Important Yeast. Chinese Journal of Blood Transfusion 16:209-211. (In Chinese). Sun, Z.X. and Wang, R.X. (2009). Present Status and Future Prospects of Bioactive Proteins from Edible Fungi. Acta Edulis Fungi 12:85-90. (in Chinese with English abstract). Tsai, L.L. (2007). Immunomodulatory protein cloned from Ganoderma microsporum. Patent. US Wang, P.H., Hsu, C.I., Tang, S.C., Huang, Y.L., Lin, J.Y. and Ko, J.L. (2004). Fungal Immunomodulatory Protein from Flammulina velutipes Induces Interferon-γ Production Through p38 Mitogen-Activated Protein Kinase Signaling Pathway. Agricultural and Food Chemistry 52:2721-2725. Wang, X.L., Liang, C.Y., Li, H.R., Li, B.Z. and Sun, F. (2010). Recombinant Ganoderma lucidum Immunoregulatory Protein ( rLZ-8) Induces Nuclear-Stress Apoptosis in K562 Cells. Cellular & Molecular Immunology 26:616-623. Wasser, S.P. (2002). Medicinal Mushrooms as a Source of Antitumor and Immunomodulating Polysaccharides. Applied Microbiology and Biotechnology 60:258-274. Wasser, S.P. (2011). Current Findings, Future Trends, and Unsolved Problems in Studies of Medicinal Mushrooms. Applied Microbiology and Biotechnology 89:1323-1332. Wichers, H. (2009). Immunomodulation by Food: Promising Concept for Mitigating Allergic Disease? Analytical and Bioanalytical Chemistry 395:37-45. 7601808B2