Integrates important new material on the structure of chromosomes including the roles of SMC proteins and cohesins the features of chromosomal DNA, and the organization of genes in DNA 25 DNA Metabolism 25.1 DNA Rep 25.2 DNA Repair 25.3 DNA Recombination Adds a section on the"replication factories"of bacterial DNA Includes latest perspectives on DNA recombination and repair 26 RNA Metabolism 26.1 DNA-Dependent Synthesis of RNA 26. 2 RNA Processing 26.3 RNA-Dependent Synthesis of RNA and DNA Updates coverage on mechanisms of mRNA processing Adds a subsection on the 5 cap of eukaryotic mRNAs Adds important new information about the structure of bacteria/ RNa polymerase and its mechanism of action 27. Protein metabolism 27. 1 The genetic Code 27.2 Protein Synthesis 27.3 Protein Targeting and Degradation Includes a presentation and analysis of the long-awaited structure of the ribosome -one of the most important updates in this new edition Adds a new box on the evolutionary significance of ribozyme-catalyzed 28. Regulation of Gene Expression 28.1 Principles of Gene Regulation 28.2 Regulation of Gene Expression in Prokaryotes 28.3 Regulation of Gene Expression in Eukaryotes Adds a new section on RNA interference(RNAi, including the medical potentia/ of gene silencingIntegrates important new material on the structure of chromosomes, including the roles of SMC proteins and cohesins, the features of chromosomal DNA, and the organization of genes in DNA 25. DNA Metabolism 25.1 DNA Replication 25.2 DNA Repair 25.3 DNA Recombination Adds a section on the "replication factories" of bacterial DNA Includes latest perspectives on DNA recombination and repair 26. RNA Metabolism 26.1 DNA-Dependent Synthesis of RNA 26.2 RNA Processing 26.3 RNA-Dependent Synthesis of RNA and DNA Updates coverage on mechanisms of mRNA processing Adds a subsection on the 5' cap of eukaryotic mRNAs Adds important new information about the structure of bacterial RNA polymerase and its mechanism of action. 27. Protein Metabolism 27.1 The Genetic Code 27.2 Protein Synthesis 27.3 Protein Targeting and Degradation Includes a presentation and analysis of the long-awaited structure of the ribosome- -one of the most important updates in this new edition Adds a new box on the evolutionary significance of ribozyme-catalyzed peptide synthesis. 28. Regulation of Gene Expression 28.1 Principles of Gene Regulation 28.2 Regulation of Gene Expression in Prokaryotes 28.3 Regulation of Gene Expression in Eukaryotes Adds a new section on RNA interference (RNAi), including the medical potential of gene silencing