A Nove/ MR Agent for Tumor Angiogenesis Evaluation Long and Narrow Linear Molecules Could Penetrate Tumor Endothelium Conceptual Illustration coiled molecule interstitium Paramagnetic ion,G● linear molecule lumen small molecule Chelator DTPA o matrix endothelium Backbone polymer, polylysine peptide Agent Endothelium Penetration Agent Synthesis Genomics and Molecular imaG e n o m i c s a n d M o l e c u l a r I m a g i n g Long and Narrow Linear Molecules Could Penetrate Tumor Endothelium interstitium matrix endothelium lumen Agent Endothelium Penetration coiled molecule small molecule linear molecule Paramagnetic ion, Gd Chelator, DTPA Backbone polymer, polylysine peptide Agent Synthesis Conceptual Illustration A Novel MR Agent for Tumor Angiogenesis Evaluation