CNS Disease: Comprehensive Imaging Program Approach and opportunity Opportunity: disease modify ing therapy Expanding to Diagnostic Agents pipeline Early differential diagnosis Disease Focus Diagnosis to affect therapy choice ·A| zheimer’ s disease and other dementia outcome AB processing, aggregation, and Surrogate for disease modifying claims clearance Diagnostic-therapeutic co-development Brain iron metabolism and overload Application of high field (3T)MRI Inflammation and the role of microglia Development of molecular imaging agent(s) Multiple Sclerosis Disease pathogenesis molecular Autoimmune response and inflammation mechanisms Platform Technologies argets 3T MR Imaging Molecular Imaging Agents-03 Structural mri Ab and nft burden · Brain iron imaging Targets in inflammatory cascade Proton Spectroscopy Apoptosis .Platform Technologies Molecular mechanisms Brain tissue analysis, histolog Role of metals in neurotoxicity Model of brain iron metabolism · Quantitative MR Computer-aided prognosticsG e n o m i c s a n d M o l e c u l a r I m a g i n g Approach and opportunity • Opportunity: disease modifying therapy pipeline • Early differential diagnosis • Diagnosis to affect therapy choice & outcome • Surrogate for disease modifying claims • Diagnostic-therapeutic co-development • Application of high field (3T) MRI • Development of molecular imaging agent(s) • Disease pathogenesis & molecular mechanisms CNS Disease: Comprehensive Imaging Program Expanding to Diagnostic Agents Disease Focus • Alzheimer’s disease and other dementia • Ab processing, aggregation, and clearance • Brain iron metabolism and overload • Inflammation and the role of microglia • Multiple Sclerosis • Autoimmune response and inflammation Targets •Molecular Imaging Agents – ‘03 • Ab and NFT burden • Targets in inflammatory cascade • Apoptosis •Molecular Mechanisms • Role of metals in neurotoxicity • Model of brain iron metabolism Platform Technologies •3T MR Imaging • Structural MRI • Brain iron imaging • Proton Spectroscopy •Platform Technologies • Brain tissue analysis, histology, ex vivo imaging • Quantitative MRI •Computer-aided prognostics