2 Protease/matrix/Cancer cell invasion/Angiogenesis Proteases:Degradation of ECM and Cell Associated Proteins MMPs Marix metallo proteinases),membrane-anchored MMP 2,MMP 9,(Cancer Cell) Soluble MMP (fibro,EC) Adamalysin -related membrane proteinases BMP 1 metalloproteinases Tissue serine proteinases Inhibitors tPA PAI UK TIMPs Tissue inhibitor of MMPs) Thrombin PEX Degradation product of Plasmin ECM by MMP 2) uPA(EC,fibro.）-→uPAR(Cancer） ZY制作 15ZYY制作 15 Protease / matrix / Cancer cell invasion / Angiogenesis Proteases: Degradation of ECM and Cell Associated Proteins MMPs ( Marix metallo proteinases), membrane - anchored MMP 2, MMP 9, (Cancer Cell) Soluble MMP (fibro, EC) Adamalysin – related membrane proteinases BMP 1 metalloproteinases Tissue serine proteinases tPA UK Thrombin Plasmin uPA ( EC, fibro. ) → uPAR ( Cancer ) Inhibitors PAI TIMPs ( Tissue inhibitor of MMPs) PEX ( Degradation product of ECM by MMP 2 )