Procedure of parameter estimation 上岸充通大学 SHANGHAI JIAO TONG UNIVERSITY Estimation error (L2):Simulated _--Measured Adjust model parameters to minimize Eor Here,M is the number of measured variables. using the Nelder-Mead (N-M)method (1)Systemic vascular compliance (Csy) Input (Measured data (2)Left ventricular passive elastance(Ev) Input data: (3)Left ventricular active elastance (Eia) (1)Mean venous pressure(Pv) (4④ Systemic vascular resistance (Ry) ② Mean pulmonary arterial pressure (Ppu 5) Right ventricular active elastance(Ev 3 Mean arterial pressure(P () Cardiac output (CO) 5) End-systolic LV volume (Viv.e) Output Physiological physical indices: (1)Height 2 Weight Estimated patient-specific values of model BSA (calculated from height and weight) parameters ④ HR 2 Computed hemodynamic quantitiesProcedure of parameter estimation Input data: (1) Mean venous pressure (Pvc) (2) Mean pulmonary arterial pressure (Ppua) (3) Mean arterial pressure (Paｒｔ) (4) Cardiac output (CO) (5) End-systolic LV volume (Vlv,es) Physiological & physical indices: (1) Height (2) Weight (3) BSA (calculated from height and weight) (4) HR (1) Systemic vascular compliance (Csys) (2) Left ventricular passive elastance (Elvb) (3) Left ventricular active elastance (Elva) (4) Systemic vascular resistance (Rsys) (5) Right ventricular active elastance (Erva) 2 , , , 1 ( ) 1 j m j s j m M j rror a a a M E − = Σ = Estimation error（L2）: Here, M is the number of measured variables. Input (Measured data ) Adjust model parameters to minimize Error using the Nelder-Mead (N-M) method Output (1) Estimated patient-specific values of model parameters (2) Computed hemodynamic quantities Simulated Measured