Local sensitivity analysis 上游充通大粤 SHANGHAI JIAO TONG UNIVERSITY parameter Ppua m Paor m 00 Vmax l Vmin lv Cvca -0106 -0.078 -0.0741 -0.0742 -0.0745 yca 0007 0.0055 0.0059 00057 00054 Rvca -00634 -0.0414 -0.0462 -00442 -00409 Cpua 00449 0.0341 0.0398 0.0386 00365 Available clinical data: ypua -0011 -0.0071 -0.0078 -0.0076 -0.0075 Rpua 02225 -0.0525 -0.0565 -00552 -0.053 Cpuc 01829 -01397 -01338 -01338 -01339 (1)Mean venous pressure(Pv) ypuc -00005 0.0001 0 0.0001 00001 (2)Mean pulmonary arterial pressure(Ppua) Rpuc 02091 -0.0712 -0.0712 -0.071 -0.0706 (3)Mean arterial pressure(Pan) Cpuv -00684 -0.029 -0.0273 -0.0274 -0.0275 ypuv -00189 0.0151 0.0151 0.015 00148 (4)Cardiac output(CO) Rpuv 0056 -0.026 -0.0258 -0.0257 -0.0256 (5)End-systolic LV volume(VNes) Caor -01186 -0.0196 -0.0176 -01515 -0375 yaor 0.0062 -0.0057 -0.0056 0.0146 0.0483 Raor -00164 0.0151 0.0149 -0.0388 -01283 yart 0 0 0 0.0001 0.0002 Rart 00046 05473 -0.0857 0.0947 Ccap -00016 -0.0008 -0.0007 -0.0015 -00029 Parameters to which the model- ycap 0 0 0.0001 00003 Rcap 00005 02561 -0.0406 0.0425 01819 simulated counterparts of Cven -03875 -02867 -02739 -0274 -02741 yven -0.0006 -0.0004 -0.0004 -0.0004 -0.0004 clinical data are most sensitive: Rven 02889 -01774 -021 -01979 -01778 Eraa 0.0308 0.0218 0.0238 0.0229 00214 (1) Total peripheral resistance(R) Erab 00649 0.0565 0.0583 0.0569 00545 Erva 01693 01205 0.1305 0124 01133 (2) Systemic venous compliance(Cven) Ervb 03654 -02488 -02756 -02641 -02449 Elaa -00211 0.0174 0.0173 0.0172 0017 (3) Right ventricular passive elastance (Ervb) Elab 00614 -0.0019 -0.0019 -0.0021 -0.0023 Elva -00592 0.0958 0.0957 -01829 08481 (4 Left ventricular passive elastance(EM) Elvb 02977 0174 -01726 -01765 -01828 ytv -00333 -0.0228 -0.0252 -0.0241 -00224 (5) Left ventricular active elastance(E) Btv -0.0042 -0.0024 -0.0027 -00026 -00024 Rtv -00202 -00127 -0.0142 -0.0136 -00125 YDV 00782 0.0588 0064 00612 00566 Bpv -00091 -0.0063 -0.0068 -0.0069 -0.007 Rpv -00169 -0.0117 -0.0127 -00127 -00127 Percentage change of predicted ymv 0.0075 -0.0033 -0.0033 -0.0033 -0.0033 hemodynamic variable Bmv 0.0045 -0.0017 -0.0017 -00017 -00017 Rmv 00167 -0.0081 -0.008 -00079 -00079 Sensitivity gain yav -00274 0.0242 0.0239 -0064 02106 Percentage change of model Bav -00009 0,0009 0.0009 -00023 -00075 parameter Rav 00002 -0.0002 -0.0002 0.0005 00017Available clinical data: (1) Mean venous pressure (Pvc) (2) Mean pulmonary arterial pressure (Ppua) (3) Mean arterial pressure (Part) (4) Cardiac output (CO) (5) End-systolic LV volume (Vlv,es) Parameters to which the model￾simulated counterparts of clinical data are most sensitive: (1) Total peripheral resistance (Rt ) (2) Systemic venous compliance (Cven) (3) Right ventricular passive elastance (Ervb) (4) Left ventricular passive elastance (Elvb) (5) Left ventricular active elastance (Elva) Sensitivity gain = Percentage change of predicted hemodynamic variable Percentage change of model parameter Local sensitivity analysis