BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 ON BOARD esponsive swell ￥ADH ￥△T ￥△c( change in concentration of a molecule Tissue-like structure/properties Form swollen networks similar to collagen, elastin, proteoglycans General areas of application in bioengineering Controlled release ON BOARD Controlled rele Tissue barriers(Hubbell? Prevent thrombosis(vessel blocked by coagulating platelets)and restenosis(re-narrowing of blood vessel after operation) in vessels after vascular injurylangioplastyletc. Prevent tissue-tissue adhesion after an operation Tissue barriers and conformal coatings Adsorbed layer of Blood vessel vessel Photoinitiator solution Two layers of Green laser formed in situ 2=H-c-0(H)c-c=o2 late solutio (An and Hubbell 2000) Lecture 7-Hydrogels 1 40f15BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 7 – Hydrogels 1 4 of 15 ON BOARD: Responsive swelling ¥ ∆pH ¥ ∆T ¥ ∆c (change in concentration of a molecule • Tissue-like structure/properties ƒ Form swollen networks similar to collagen, elastin, proteoglycans • General areas of application in bioengineering: • Controlled release ON BOARD: Controlled release • Tissue barriers (Hubbell2,3) ƒ Prevent thrombosis (vessel blocked by coagulating platelets) and restenosis (re-narrowing of blood vessel after operation) in vessels after vascular injury/angioplasty/etc. ƒ Prevent tissue-tissue adhesion after an operation Tissue barriers and conformal coatings (An and Hubbell 2000) Adsorbed layer of Blood photoinitiator vessel Photoinitiator solution PEG-diacrylate solution Green laser 3) 2) 1) Two layers of hydrogel formed in situ vessel