BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 TE scaffolds/cell encapsulation/immunoisolation. 5 Colloidal crystal template Poly(methyl methacrylate) microspheres 1. Perfect connectivity for Filling of the interstices cell migration atrix or wi 2. Improved nutrient nanoparticles Hydrogel 3. No dead volume precursor polymerize Ordered Dissolve porous microspheres 签签 structure Structured porous replica A M. Lenhoff. CuT. Hydrogel @verse opals Optical micrograph/20 um pores Fluorescence micrograph/60 um pores Biosensors( to be covered later) Contact lenses Lecture 7-Hydrogels 1 5of15BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 • TE scaffolds/cell encapsulation/immunoisolation4,5 Poly(methyl methacrylate) microspheres Perfect connectivity for cell migration Improved nutrient transport No Ôdead volumeÕ O.D. Velev and A.M. Lenhoff, Curr. Opin. Coll. Interf. Sci. 5, 56 (2000) Advantages: 1. 2. 3. Hydrogel precursor polymerize Dissolve microspheres Ordered porous structure Hydrogel Ôinverse opalsÕ Optical micrograph/20 µm pores 60 µm Fluorescence micrograph/60 µm pores • Biosensors (to be covered later) • Contact lenses Lecture 7 – Hydrogels 1 5 of 15