骨髓增生异常综合征的历史 Leu res2012,36:1441-52 Early history Evolution of classification of Myelodysplastic Syndromes il morbo di Guglielmo (1920s) Refractory anemia (1938) 1976 Preleukemia anemia 1982 (1949/1953) French-American-British(FAB French-American-British(FAB) Co-operative Group Group Myelodysplastic diopathic acquired Leukemia Classification Syndromes Classification sideroblastic anemia (1956) Smoldering acute 2 categories of 5 categories of leukemia (1963) dysmyelopoietic syndromes myelodysplastic syndromes RAEB and CMML RA, RARS, RAEB, RAEB-t CMML "Preleukemia 1976年前,MDS的名称 并不存在 2008 1999(draft)/2001(final) ??? 4 World Health Organization (WHO) 3d World Health Organization(WHO) Classification of Tumours of Haematopoietic Classification of Tumours of Haematopoietic and Lymphoid Tissues and Lymphoid Tissues -l1 MDS categories M10 MDS categories Changes from 20o1 WHo system; Changes from 1982 FAB_systemi Added: RN and rT (with RA, comprise RCUD), Added: RCMD, RCMD-RS, MDS with del(5q), MDS-U, childhood MDS (including provisional RCC t-MDS/t-AML due to alkylators Merged: RCMD with RCMD-RS t-MDS/t-AML due to topoisomerase ll inhibitors t-MDS/t- AML due to any cause Divided: RAEB into RAEB-l and-2 Refined: MDS-U Moved: CMML (to MDS/MPD)Eliminated: RAEB-t骨髓增生异常综合征的历史 Leu Res 2012, 36:1441-52. 1976年前，MDS的名称 并不存在