Ras farnesyl protein transferase inhibitors Ras goes through four steps of modification: isoprenylation, proteolysis, methylation and palmitoylation Farnesylation is necessary to attach Ras to the cell membrane for it to transfer signals from membrane receptors Lead: CAAX tetrapeptide inhibitors Growth factor receptor kinase ILK (CASPASE9 Nucleus Transcription /ProliferationWuXiͲ Genentech MedChem Team 5 Ras farnesyl protein transferase inhibitors ¾ Ras goes through four steps of modification: isoprenylation, proteolysis, methylation and palmitoylation. Farnesylation is necessary to attach Ras to the cell membrane, for it to transfer signals from membrane receptors. Lead: CAAX tetrapeptide inhibitors