Ras farnesyl protein transferase inhibitors CAAX tetrapeptide to CAAX aminomethyl isosteres Intramolecular reaction with lactone 2N H2N Bioorganic Medicinal Chemistry, 2, 939-947, 1994WuXiͲ Genentech MedChem Team 6 Ras farnesyl protein transferase inhibitors Bioorganic & Medicinal Chemistry, 2, 939Ͳ947, 1994 ¾ CAAX tetrapeptide to CAAX aminomethyl isosteres ¾ Intramolecular reaction with lactone H N N O H2N HS NH O OH 3