Yano et al Page 13 Amireault P, Sibon D, Cote F. Life without peripheral serotonin: insights from tryptophan hydroxylase I knockout mice reveal the existence of paracrine/autocrine serotonergic networks. ACS chemical neuroscience. 2013: 4: 64-71.[PubMed: 23336045 Appleby RN, Walters JR. The role of bile acids in functional GI disorders. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2014; 26: 1057- 1069.[ PubMed:24898156] Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota Nature. 2013: 500: 232-236[PubMed: 23842501 Baganz NL, Blakely RD. a dialogue between the immune system and brain, spoken in the language of serotonin. ACs chemical neuroscience. 2013: 4: 48-63 23336044 Bonnin A, Goeden N, Chen K, wilson ML, King j, Shih Jo ly RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 2011; 472: 347-350. [PubMed 21512572] Brigelius-Flohe R, Traber MG. Vitamin E: function and metabolism. FASEB journal official publication of the Federation of American Societies for Experimental Biology. 1999; 13: 1145- 1155.[ PubMed:10385606] c9 Chabbi-Achengli Y, Coudert AE, Callebert J, Geoffroy V, Cote F, Collet C, de vernejoul MC. Decreased osteoclastogenesis in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 2012: 109: 2567-2572. [PubMed: 22308416 Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex- dependent manner. Molecular psychiatry. 2013: 18: 666-673 [PubMed: 22688187] Collins sm. The immun lation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology. 1996; 111: 1683-1699 [PubMed: 8942751 Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G Maternal serotonin crucial for murine embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104: 329-334 [PubMed: 17182745] Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F Lechat P, et al. Disruption of the nonneuronal tphl gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America.2003,100:13525-13530.[ PubMed:14597720 de crecy- Lagard V, El Yacoubi B, de la Garza RD, Noiriel A, Hanson AD Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC genomics. 2007; 8:245.[ PubMed:17645794] Dewhirst FE, Chien CC, Paster BJ, Ericson RL, Orcutt RP, Schauer DB, Fox JG. Phylogeny of the defined murine microbiota: altered Schaedler flora. Applied and environmental microbiology 1999,65:3287-3292.[ PubMed:10427008] Ducy P, Karsenty G. The two faces of serotonin in bone biology. The Journal of cell biology. 2010 191:7-13.[PL Fukumoto S, Tatewaki M, Y amada T, Fujimiya M, Mantyh C, Voss M, Eubanks S, Harris M, Pappas TN, Takahashi T. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. American journal of physiology Regulatory, integrative and comparative physiology. 2003 284:R1269-R1276. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007; 132: 397-414.[PubMed: 17241888] loffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, et al. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity Gastroenterology. 2012: 142: 844-854 844.[ PubMed:22226658] Li Z, Chalazonitis A, Huang YY, Mann JJ, Margolis KG, Yang QM, Kim DO, Cote F, Mallet J Gershon MD. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience: the official ournal of the Society for Neuroscience. 2011; 31: 8998-9009[PubMed: 21677183 Cell. Author manuscript; available in PMC 2016 April 09Amireault P, Sibon D, Cote F. Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks. ACS chemical neuroscience. 2013; 4:64–71. [PubMed: 23336045] Appleby RN, Walters JR. The role of bile acids in functional GI disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2014; 26:1057– 1069. [PubMed: 24898156] Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013; 500:232–236. [PubMed: 23842501] Baganz NL, Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS chemical neuroscience. 2013; 4:48–63. [PubMed: 23336044] Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 2011; 472:347–350. [PubMed: 21512572] Brigelius-Flohe R, Traber MG. Vitamin E: function and metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1999; 13:1145– 1155. [PubMed: 10385606] Chabbi-Achengli Y, Coudert AE, Callebert J, Geoffroy V, Cote F, Collet C, de Vernejoul MC. Decreased osteoclastogenesis in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109:2567–2572. [PubMed: 22308416] Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex￾dependent manner. Molecular psychiatry. 2013; 18:666–673. [PubMed: 22688187] Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology. 1996; 111:1683–1699. [PubMed: 8942751] Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G. Maternal serotonin is crucial for murine embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104:329–334. [PubMed: 17182745] Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100:13525–13530. [PubMed: 14597720] de Crecy-Lagard V, El Yacoubi B, de la Garza RD, Noiriel A, Hanson AD. Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC genomics. 2007; 8:245. [PubMed: 17645794] Dewhirst FE, Chien CC, Paster BJ, Ericson RL, Orcutt RP, Schauer DB, Fox JG. Phylogeny of the defined murine microbiota: altered Schaedler flora. Applied and environmental microbiology. 1999; 65:3287–3292. [PubMed: 10427008] Ducy P, Karsenty G. The two faces of serotonin in bone biology. The Journal of cell biology. 2010; 191:7–13. [PubMed: 20921133] Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, Eubanks S, Harris M, Pappas TN, Takahashi T. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. American journal of physiology Regulatory, integrative and comparative physiology. 2003; 284:R1269–R1276. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007; 132:397–414. [PubMed: 17241888] Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, et al. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology. 2012; 142:844–854. e844. [PubMed: 22226658] Li Z, Chalazonitis A, Huang YY, Mann JJ, Margolis KG, Yang QM, Kim DO, Cote F, Mallet J, Gershon MD. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31:8998–9009. [PubMed: 21677183] Yano et al. Page 13 Cell. Author manuscript; available in PMC 2016 April 09. Author Manuscript Author Manuscript Author Manuscript Author Manuscript