Yano et al Page 14 obato KR, Cardoso CC, Binfare RW, Budni J, Wagner CL, Brocardo PS, de Souza lf, Brocardo C, Flesch S, Freitas AE, et al. alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression. Behavioural brain research. 2010; 209: 249-259 [ PubMed:20144659] Maes M, De Vos N, Pioli R, Demedts P, Wauters A, Neels H, Christophe A Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness Journal of affective disorders. 2000; 58: 241-246.[PubMed: 10802134 Marcobal A, De las Rivas B, Landete JM, Tabera L, Munoz R. Tyramine and phenylethy lami biosynthesis by food bacteria. Critical reviews in food science and nutrition. 2012: 52: 448467 [ PubMed:22369263] Mawe GM, Hoffman JM. Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets. Nature reviews Gastroenterology hepatology. 2013: 10: 473-486 Mc Vey Neufeld KA, Mao YK, Bienenstock J, Foster JA, Kunze WA. The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2013: 25: e183- e88.[ PubMed:23281940 Mercado CP, Quintero MV, Li Y, Singh P, Byrd AK, Talabnin K, Ishihara M, Azadi P, Rusch N Kuberan B, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Scientific reports.2013,3:2795.[ PubMed:24077408] Muller PA, Koscso B, Rajani Gm, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, et al. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell. 2014; 158: 300-313 [PubMed: 25036630] narushima S, Itoha K, Miyamoto Y, Park SH, Nagata K, Kuruma K, Uchida K. Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria. Lipids. 2006, 41: 835- 3.[ PubMed:17152920 OMahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. behavioural brain research. 2014 Odell TT Jr, Mc DT. Life span of mouse blood platelets. Proc Soc Exp Biol Med. 1961; 106: 107-10 Oleskin AV, Kirovskaia TA, Botvinko IV, Lysak LV. Effect of serotonin(5-hydroxytryptamine)on the growth and differentiation of microorganisms. Mikrobiologiia. 1998: 67: 305-312.[PubMed Owen AJ, Batterham M, Probst YC, Grenyer BF, Tapsell LC Low plasma vitamin E levels in major depression: diet or disease? European journal of clinical nutrition. 2005: 59: 304-306. [ PubMed 15508016] Quigley EM. Microflora modulation of motility. Journal of neurogastroenterology and motility. 2011 17:140-147.[ PubMed:21602990 Ramage AG, Villalon CM. 5-hydroxytryptamine and cardiovascular regulation. Trends in pharmacological sciences. 2008; 29: 472-481. [ PubMed: 19086344 Roshchina VV. Evolutionary Considerations of Neurotransmitters in Microbial, Plant, and Animal Cells. Microbial Endocrinology. 2010: 17-52 Savelieva Kv, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH. Genetic disruption of both tryptophan hydroxy lase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLos One. 2008; 3: e3301. [PubMed: 18923670 Sayin SI, Wahlstrom A, Felin J, Jantti S, Marschall HU, Bamberg K, Angelin B, Hyotylainen T Oresic M, Backhed F Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell metabolism. 2013: 17: 225- 235. [PubMed:23395169] Shimizu t, shimizu s, Hattori R, Gabazza EC, Majima Y In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. American journal of respiratory and critical care medicine. 2003: 168: 581-587 [PubMed: 12829454] Sjogren K, Engdahl C, Henning P, Lerner UH, Tremaroli V, Lagerquist MK, Backhed F, Ohlsson C he gut microbiota regulates bone mass in mice. J Bone Miner Res 2012: 27: 1357-1367 [ PubMed:22407806 Cell. Author manuscript; available in PMC 2016 April 09Lobato KR, Cardoso CC, Binfare RW, Budni J, Wagner CL, Brocardo PS, de Souza LF, Brocardo C, Flesch S, Freitas AE, et al. alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression. Behavioural brain research. 2010; 209:249–259. [PubMed: 20144659] Maes M, De Vos N, Pioli R, Demedts P, Wauters A, Neels H, Christophe A. Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness. Journal of affective disorders. 2000; 58:241–246. [PubMed: 10802134] Marcobal A, De las Rivas B, Landete JM, Tabera L, Munoz R. Tyramine and phenylethylamine biosynthesis by food bacteria. Critical reviews in food science and nutrition. 2012; 52:448–467. [PubMed: 22369263] Mawe GM, Hoffman JM. Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets. Nature reviews Gastroenterology & hepatology. 2013; 10:473–486. McVey Neufeld KA, Mao YK, Bienenstock J, Foster JA, Kunze WA. The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2013; 25:e183– e188. [PubMed: 23281940] Mercado CP, Quintero MV, Li Y, Singh P, Byrd AK, Talabnin K, Ishihara M, Azadi P, Rusch NJ, Kuberan B, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Scientific reports. 2013; 3:2795. [PubMed: 24077408] Muller PA, Koscso B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, et al. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell. 2014; 158:300–313. [PubMed: 25036630] Narushima S, Itoha K, Miyamoto Y, Park SH, Nagata K, Kuruma K, Uchida K. Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria. Lipids. 2006; 41:835– 843. [PubMed: 17152920] O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behavioural brain research. 2014 Odell TT Jr, Mc DT. Life span of mouse blood platelets. Proc Soc Exp Biol Med. 1961; 106:107–108. [PubMed: 13730268] Oleskin AV, Kirovskaia TA, Botvinko IV, Lysak LV. Effect of serotonin (5-hydroxytryptamine) on the growth and differentiation of microorganisms. Mikrobiologiia. 1998; 67:305–312. [PubMed: 9702725] Owen AJ, Batterham MJ, Probst YC, Grenyer BF, Tapsell LC. Low plasma vitamin E levels in major depression: diet or disease? European journal of clinical nutrition. 2005; 59:304–306. [PubMed: 15508016] Quigley EM. Microflora modulation of motility. Journal of neurogastroenterology and motility. 2011; 17:140–147. [PubMed: 21602990] Ramage AG, Villalon CM. 5-hydroxytryptamine and cardiovascular regulation. Trends in pharmacological sciences. 2008; 29:472–481. [PubMed: 19086344] Roshchina VV. Evolutionary Considerations of Neurotransmitters in Microbial, Plant, and Animal Cells. Microbial Endocrinology. 2010:17–52. Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008; 3:e3301. [PubMed: 18923670] Sayin SI, Wahlstrom A, Felin J, Jantti S, Marschall HU, Bamberg K, Angelin B, Hyotylainen T, Oresic M, Backhed F. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell metabolism. 2013; 17:225– 235. [PubMed: 23395169] Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. American journal of respiratory and critical care medicine. 2003; 168:581–587. [PubMed: 12829454] Sjogren K, Engdahl C, Henning P, Lerner UH, Tremaroli V, Lagerquist MK, Backhed F, Ohlsson C. The gut microbiota regulates bone mass in mice. J Bone Miner Res. 2012; 27:1357–1367. [PubMed: 22407806] Yano et al. Page 14 Cell. Author manuscript; available in PMC 2016 April 09. Author Manuscript Author Manuscript Author Manuscript Author Manuscript