Powder filling ®生Design of Powder Formulation 柱塞 General Considerations ·Lubricity 1防 ·Compactibility 。Fluidity 填充管 ]T仔单位重药指块 放表 @卢t生Design of Powder Formulation Manufacture of Hard Capsules ©Excipients ©Nonpowder filling ·Fillers ·Beads/pellets ·Glidants ·Microtablets 。Lubricants ·Liquid ·Disintegrants 国垫生 ©f达Soft Gelatin Capsules(softgels) Alternatives to Gelatin Capsules ·Starch capsules The moisture content of the capsules is 14%. ·HPMC capsules Lower moisture content than gelatin capsules The moisture is tighter bound 44 Powder filling Shanghai Jiao Tong University Design of Powder Formulation General Considerations • Lubricity • Compactibility • Fluidity Shanghai Jiao Tong University Design of Powder Formulation Excipients • Fillers • Glidants • Lubricants • Disintegrants Shanghai Jiao Tong University Manufacture of Hard Capsules Nonpowder filling • Beads/pellets • Microtablets • Liquid Shanghai Jiao Tong University Alternatives to Gelatin Capsules • Starch capsules • The moisture content of the capsules is 14%. • HPMC capsules • Lower moisture content than gelatin capsules • The moisture is tighter bound Shanghai Jiao Tong University Soft Gelatin Capsules (softgels)