图生_Manufacture of Hard Capsules ®i生_Manufacture of Hard Capsules ©Size ④Self-locking closure ·Eight size::000,00,0,1,2,3,4,5 Hard capsules are made self-locking by forming indentations or grooves 空数01234 on the inside of the cap 0750.550.400200.25015 and body portions 圈t生Manufacture of Hard Capsules Manufacture of Hard Capsules ©Storage of shells ©Rectification Avoid extremely temperature(s37C) Separation of caps from bodies Maintain a relative humidity of 50% Dosing of fill material ④Stability of shells Replacement of caps and ejection of filled capsules Moisture transfer between content and shell ·Trace aldehydes 8-ee-9-ggg-月-3 Manufacture of Hard Capsules 国生 Manual Filling Machines ®Powder filling ·Choice of shell ·Power filling Sealing 33 Shanghai Jiao Tong University Manufacture of Hard Capsules Size • Eight size: 000, 00, 0, 1, 2, 3, 4, 5 Shanghai Jiao Tong University Manufacture of Hard Capsules Self-locking closure • Hard capsules are made self-locking by forming indentations or grooves on the inside of the cap and body portions Shanghai Jiao Tong University Manufacture of Hard Capsules Storage of shells • Avoid extremely temperature(≤ 37℃) • Maintain a relative humidity of 50% Stability of shells • Moisture transfer between content and shell • Trace aldehydes Shanghai Jiao Tong University Manufacture of Hard Capsules Rectification Separation of caps from bodies Dosing of fill material Replacement of caps and ejection of filled capsules Shanghai Jiao Tong University Manufacture of Hard Capsules Powder filling • Choice of shell • Power filling • Sealing Shanghai Jiao Tong University Manual Filling Machines