图生 Gelatin 国上人生 Gelatin Although some other materials could be used. Type A gelatin contributes plasticity and clarity Manufactured from pork skin gelatin is the most popular component to prepare capsule shells. Produced by acid hydrolysis .Isoelectric point:7-9 Gelatin is prepared by the hydrolysis of collagen obtained from animal connective Type B gelatin contributes firmness Manufactured from bone tissue,bones,skin,and sinew. Produced by alkaline hydrolysis Isoelectric point:4.7-5.2 国生一 Manufacture of Hard Capsules Evaluation of gelatin Shell composition ·Gel strength冻力强度 Gelatin Plasticizer:glycerin ·Viscosity ·Thicker Opaquing agents ·Preservatives ·Colorants Water 国生一 Manufacture of Hard Capsules Manufacture of Hard Capsules ©Shell manufacture Properties of empty capsules ·Gelatin dissolution ·Appearance: ·Dipping ·Size ·Smel .Rotation Moisture content:13.0-16.0% ·Drying ·Friability ·Stripping ·Dissolution rate .Trimming ·Ash test ·Joining .Microbiological test 22 Shanghai Jiao Tong University Gelatin Although some other materials could be used, gelatin is the most popular component to prepare capsule shells. Gelatin is prepared by the hydrolysis of collagen obtained from animal connective tissue, bones, skin, and sinew. Shanghai Jiao Tong University Gelatin Type A gelatin contributes plasticity and clarity • Manufactured from pork skin • Produced by acid hydrolysis • Isoelectric point: 7-9 Type B gelatin contributes firmness • Manufactured from bone • Produced by alkaline hydrolysis • Isoelectric point: 4.7-5.2 Shanghai Jiao Tong University Evaluation of gelatin • Gel strength 冻力强度 • Viscosity Shanghai Jiao Tong University Manufacture of Hard Capsules Shell composition • Gelatin • Plasticizer: glycerin • Thicker • Opaquing agents • Preservatives • Colorants • Water Shanghai Jiao Tong University Manufacture of Hard Capsules Shell manufacture • Gelatin dissolution • Dipping • Rotation • Drying • Stripping • Trimming • Joining Shanghai Jiao Tong University Manufacture of Hard Capsules Properties of empty capsules • Appearance: • Size • Smell • Moisture content: 13.0–16.0% • Friability • Dissolution rate • Ash test • Microbiological test