Hallmarks of cancer (Weinberg. Cell, 2000) Sustaining proliferative signaling Resisting Evading growth cell death suppressors Inducing Activating invasion angiogenesIs and metastasis Enabling replicative immortality Figure 1. The hallmarks of cancer this illustration encompasses the six hallmark capabilitie originally proposed in our 2000 perspective. The past decade has witnessed remarkable progress toward understanding the mechanistic underpinnings of each hallmark.(Hanahan D, Weinberg 5 RA. Hallmarks of Cancer: The Next Generation Cell 2011, 144: 646)5 Hallmarks of cancer (Weinberg, Cell, 2000) Figure 1. The Hallmarks of Cancer. This illustration encompasses the six hallmark capabilities originally proposed in our 2000 perspective. The past decade has witnessed remarkable progress toward understanding the mechanistic underpinnings of each hallmark. (Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell 2011, 144:646)