Hallmarks of cancer (Weinberg. cell, 2011) Sustaining Evading proliferative growth signaling suppressors Deregulating Avoiding cellular Immune energetics destruction Resistin Enable cell replicative death immortality G enome instability promoting mutation inflammation Inducing Activating angiogenesis invasion metastasis (Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation Cell 2011, 144: 646)66 Hallmarks of cancer (Weinberg, Cell, 2011) . (Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell 2011, 144:646)