Primary lesion-chancre Clinics -3 phases (painless) (10 to 60 days 1)skin in the place of area of ulceration /inflammation penetration shedding of spirochetes ulcus durum-primary site of replication(multiple Tsp in Secondary(2-10 weeks later) ulcus ), endarteritis a systemic spread periarteritis, infiltration of ulcer disseminated mucocutaneous with PMnl and makrophages, rash phagocytosis -spirochets are highly contagious able to survive it Tertiary (several years later) 2)Disseminated disease rare generalised skin lesions -skin multiple Tsp in blood central nervous system 3)Plate manifestation delayed hypersensitivity in any organ or tissue few organisms control by immune response 1212 • Primary lesion –chancre (painless) • (10 to 60 days) – area of ulceration/inflammation shedding of spirochetes • Secondary (2-10 weeks later) – systemic spread – disseminated mucocutaneous rash – highly contagious • Tertiary (several years later) – rare – skin, – central nervous system – delayed hypersensitivity – few organisms * control by immune response Clinics – 3 phases 1) Skin in the place of penetration ulcus durum –primary site of replication (multiple T.sp in ulcus ), endarteritis a periarteritis, infiltration of ulcer with PMNL and makrophages, phagocytosis – spirochets are able to survive it 2) Disseminated disease – generalised skin lesions multiple T.sp in blood 3) Plate manifestation in any organ or tissue