Pathogenesis OMP-outer membrane proteins promote adherence Hyaluronidase -facilitate perivascular infiltration Fibronectin - produced by Treponema pallidum coating phagoctes-anti phagocytal properties Immunopathology => tissue destruction and lesions are primarily result of hosts immune response11 Pathogenesis OMP – outer membrane proteins – promote adherence; Hyaluronidase –facilitate perivascular infiltration Fibronectín – produced by Treponema pallidum -coating phagoctes – anti phagocytal properties Immunopathology=> tissue destruction and lesions are primarily result of host’s immune response