4. Explain the Characteristics of genetic disorders population distribution modelof inheritance congenital famili infectious 5. Analyze the pedigree, what inheritance model do you think? why? AAR BXD Section C: Consulting(50%) 1. key points: albinism is ar model 2. Key points: (1) Recurrence risk increases with the number ofaffected children in a family (2) Recurrence risk increases with severity of the defect. A more severely affected parent is more likely to produce an affected child 3)Consanguinity slightly increases the risk for an affected chi (4 f the two sexes have a different probability of being affected, the least likely sex, if affected, is the most likely sex to produce an affected ofspring. 3. Key points: LHON is mitochondrial disease and just be passed down from the females. If the parents have Down syndrome children before, the risk will be higher 4. Key points: XR4. Explain the Characteristics of genetic disorders population distribution model of inheritance congenital familial infectious 5. Analyze the pedigree，what inheritance model do you think? Why? A AR B XD Section C: Consulting (50%) 1. Key points: albinism is AR model. 2. Key points: (1) Recurrence risk increases with the number of affected children in a family. (2) Recurrence risk increases with severity of the defect. A more severely affected parent is more likely to produce an affected child. (3) Consanguinity slightly increases the risk for an affected child. (4) If the two sexes have a different probability of being affected, the least likely sex, if affected, is the most likely sex to produce an affected offspring. 3. Key points: LHON is mitochondrial disease and just be passed down from the females. If the parents have Down syndrome children before, the risk will be higher. 4. Key points: XR