Shanghai Medical College of Fudan University Final Exam of Medical Genetics in 2011-2012(1) MBBS 口A ame Student number section A B C Total scores scores Section A: Choice Questions(20%) 1.C2.B3.C4.D5.A6.A7.C8.A9.D10.D Section B Term explanation short-answer questions(30%) 1. Down syndrome Trisomy 21, Short stature and obesity occurs during adolescence Moderate-to-severe mental retardation occurs, with an intelligence quotient(10)of20-85 2. Philadelphia chromosome Philadelphia chromosome show that most of chromosome 22 has been translocated onto the long arm of chromosome 9. I This translocation, which is found only in tumor cells, indicates that a patient has chronic myelogenous leukemia(CML) 3. Liability The risks of polygene disorders determined by both genes and environmentalfactorsShanghai Medical College of Fudan University Final Exam of Medical Genetics in 2011-2012 (1) MBBS □ A Name ： Student Number： section A B C Total scores scores Section A: Choice Questions(20%) 1.C 2.B 3.C 4.D 5.A 6.A 7.C 8.A 9.D 10.D Section B Term explanation & Short-answer questions(30%) 1. Down syndrome Trisomy 21, Short stature and obesity occurs during adolescence. Moderate-to-severe mental retardation occurs, with an intelligence quotient (IQ) of 20-85. 2. Philadelphia chromosome Philadelphia chromosome show that most of chromosome 22 has been translocated onto the long arm of chromosome 9. I This translocation, which is found only in tumor cells, indicates that a patient has chronic myelogenous leukemia (CML). 3. Liability The risks of polygene disorders determined by both genes and environmental factors