上商充通大￥ 后 Shanghai Jiao Tong University Pharmacokinetics Benzodiazepines: 1,oral absorption rapid usually 2,most phase one metabolites active,with half-lives greater than parent drugs accumulation of active metabolites leads to excessive sedationShanghai Jiao Tong University Pharmacokinetics Benzodiazepines: 1, oral absorption rapid usually 2, most phase one metabolites active, with half-lives greater than parent drugs accumulation of active metabolites leads to excessive sedation