DNA Sequence Alignment V How is n related to the score matrix? n is the unique positive solution to the equation pip: e= p frequency of nt i, Si= score for aligning an i,j pair What kind of an equation is this? What would happen to n if we doubled all the scores? What does this tell us about the nature of n? Karlin Altschul 1990i DNA Sequence Alignment V How is λ related to the score matrix? λ is the unique positive solution to the equation*: ∑ p pjeλsij = 1 i i,j p = frequency of nt i, sij = score for aligning an i,j pair What kind of an equation is this? What would happen to λ  if we doubled all the scores? What does this tell us about the nature of λ? *Karlin & Altschul, 1990