Activators of fever microbe: G LPS ET G peptidoglycan vIrus: enveloped virus 1. Extragenous particle: transfuse response pyrogen 2. internal production immune complexes etiocholanoloneActivators of fever microbe: G- LPS, ET G+ peptidoglycan virus: enveloped virus particle:transfuse response 2. internal production immune complexes etiocholanolone 1. Extragenou pyrogen