Fever
Fever
38℃ 38.0℃ 378℃ 38.0 37:6c 37.5°c 37℃ 36C 36.4 36℃ 359℃ 35.8035.8℃ 35℃ 伯 34℃ 0~2岁3-10岁165岁0e65岁
Normal Axillary temperature 36-37.0C Sublingual temperature 36.7-377C rectal temperature 369-379C
Normal Axillary temperature 36~37 .0 C Sublingual temperature 36.7~37.7 C rectal temperature 36.9~37.9 C
一、 Concept pyrogen set point of the thermoregulatory center I bod temperature
一、 Concept pyrogen set point of the thermoregulatory center body temperature
sport ★★★★ physiological pregnancy luteal phase T hyperthermia pathological ( set point±) fever
sport physiological T pregnancy luteal phase hyperthermia pathological T （set point ±） fever T
*Hyperthermia thermogenesis thermolysis dysfunction of thermoregulatory center
Hyperthermia : thermogenesis thermolysis dysfunction of thermoregulatory center
二、 Causes and pathogenesis of fever Pyrogen and activator of fever Activator: the substance can activate the cells that can produce the pyrogen. pyrogen: the substance can cause fever
二、 Causes and pathogenesis of fever Pyrogen and activator of fever Activator : the substance can activate the cells that can produce the pyrogen. pyrogen: the substance can cause fever
Activators of fever microbe: G LPS ET G peptidoglycan vIrus: enveloped virus 1. Extragenous particle: transfuse response pyrogen 2. internal production immune complexes etiocholanolone
Activators of fever microbe: G- LPS, ET G+ peptidoglycan virus: enveloped virus particle:transfuse response 2. internal production immune complexes etiocholanolone 1. Extragenou pyrogen
Endogenou pyrogen(EP) interleukin-1(IL-1): MC, fibroblast IL-6: T, B lymphocyte, tumor cell TNE TNFa DM TNFB (lymphotoxin)active T interferon (IFN): T lymphocyte
Endogenou pyrogen(EP) interleukin-1(IL-1) :MC,fibroblast IL-6:T,B lymphocyte,tumor cell TNF : TNFα Mφ TNFβ (lymphotoxin) active T interferon ( IFN ): T lymphocyte
1.0 IL=18 (200 ng/kg) 合 TINF-a (504gkg) 0.5 rTNF-a 的增 (500 ng/kg) rlL-1B(70℃)200ngkg) 0 30 60 120 150 180 Minutes 图12-2家兔静脉分别注射rI1B、rNF-a、rFN-a引起的发热反应