Liver fibrosis accumulation of synthesis degradation of matrix extracellular of matrix matrix in liver proteins proteins Collagens type i and l constitute more than 95% of the total content of increased collagen in fibrotic liverLiver fibrosis accumulation of extracellular matrix in liver synthesis of matrix proteins degradation of matrix proteins Collagens type I and III constitute more than 95% of the total content of increased collagen in fibrotic liver