Hepatic stellate cell activation Quiescent Activated HSC HSC Autocrine cytokines Proliferation Smooth musel. Cytokine receptor Retinoid y-actin Proliferative droplets cytokines (PDGF Fibrogenic fIbrogenic younes stimulus IGEb Signal from Fibrogenesis Kuper cells ar Type NV Matrix collagenase diced Initiation Perpetuation activation ase PhaseHepatic stellate cell activation