一个基因可编编码两种完全不同的蛋白质 p16 Ink4a E1B E1a Exon 2 Exon 3 P14ARF (human) P19ARF (mouse) Cross Talk betweren Oncogenes tumor suppressors Oncogenic Signals Ras,c-myc,E2F P14ARF p16 Ink4a (Block MDM-2/p53 binding) p53m4 DNA Damage Rb on Cell cycle arrest ZYY制作 4 ZYY制作 4 E1 b E1 a Exon 2 Exon 3 p16 Ink 4a P14 ARF (human) P19 ARF (mouse) Cross Talk betweren Oncogenes & tumor suppressors Oncogenic Signals Ras, c-myc, E2F p16 Ink 4a Rb on Cell cycle arrest P14 ARF (Block MDM-2 / p53 binding) p53 on DNA Damage 一个基因可编编码两种完全不同的蛋白质