1期 廖洁丹等:恩诺沙星及其代谢产物在奶牛乳中的消除规律 317 Song Z Y, Liu G T Current Pharmacology. Beijing: Chinese Union [20] Manceau J, Gicquel M, Laurentie M, Sanders P. Simultaneous Medical University and Beijing Medical University Unified determination of enrofloxacin and ciprofloxacin in animal biological Publishing Company, 1994: 107-122(in Chinese) fluids by high-performance liquid chromatography application in [13] Kaartinen L, Salonen M, Alli L, Pyorala S. Pharmacokinetics of pharmacokinetic studies in pig and rabbit. Journal of chromatography enrofloxacin after single intravenous, intramuscular and subcutaneous B,1999,726:175-184 ions in lactating cows. Journal of veterinary Pharmacology and [21] Knoll U, Glunder G, Kietzmann M. Comparative study of the plasma Therapeutics,1995,18(8)357-362 pharmacokinetics and tissue concentrations of danofloxacin and [14] Kaartinen L, Pyorala S, Moilanen M, Raisanen S. Pharmacokinetics of enrofloxacin in broiler chickens. Journal of veterinary Pharmacolog enrofloxacin in newbom and one-week-old calves. Journal of and Therapeutics, 1999, (2): 239-246 veterinary Pharmacology and Therapeutics, 1997, 20: 479-482 [22] Rao G S, Ramesh S, Ahmad A H, Tripathi H C, Sharma L D, Malik J [15] Sharma P K, Ahmad A H, Sharma L D, Varma R Pharma K. Disposition kinetics of enrofloxacin and ciprofloxacin following of enrofloxacin and the rate of formation of its ravenous administration of enrofloxacin in goats. Small ruminant ciprofloxacin following intravenous and intramuscular single dose Research,2002,44:9-15 administration to male buffalo calves. The Veterinary Journal, 2003, [23] Rao G S, Ramesh S, Ahmad A H, Tripathi H C, Sharma L D, Malik J 166:10l-104 K. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin [16] Rantala M, Kaartinen L, Valimaki E, Stryrman M, Hiekkaranta in goats given enrofloxacin alone and in combination with Probenecid. enrofloxacin and flunixin meglumine for treatment of cows with [24 De Lucas JJ, Rodriguez C, Martella M B, Labaque M C, Navarro JL, experimentally induced Escherichia coli mastitis. Journal of San Andres m 1. Pharmacokinetics of enrofloxacin following Veterinary Pharmacology and Therapentics, 2002, 25: 251-258 intravenous administration to greater rheas: a preliminary stud [17] Papich M G, Vancamp s D, Cole J A, Whitacre M D Research in Veterinary Science, 2005, 78: 265-267 Pharmacokinetics and endometrial tissue concentrations of [25) Shem-Tov M, Rav-on O, Ziv G, Lavi E, Glickman A, Saran A enrofloxacin and the metabolite ciprofloxacin after i.v. administration Pharmacokinetics and penetration of danofloxacin from the blood into of enrofloxacin to mares. Journal of veterinary Pharmacology and the milk of cows. Journal of Veterinary Pharmacology and Therapeutics,2002,25:343-350. Therapentics, 1998, 21: 209-213 [8] Bidgood T L, Papich M G. Plasma and interstitial fluid6]卜仕金,冯淇辉.环丙沙星在内毒素诱导的乳房炎奶山羊药动学 pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and 及乳汁和组织浓度.中国兽药学报,200020(3):271-274. marbofloxacin after oral administration and a cor Pu s J, Feng Q H. Pharmacokinetics of ciprofloxacin and its intravenous infusion in dogs. Journal of veterinary Pharmacolog concentrations in milk and udder tissues in goats with endotoxin and Therapeutics, 2005, 28: 329-341 induced mastitis. Chinese Journal of Veterinary Science, 2000, 20(3) [19] Cester CC, Toutain P L. A comprehensive model for enrofloxacin to Pharmacological Science, 1997, 86: 1148-1155 (责任编辑林鉴非 o1994-2009chinaAcademicJournalElectronicpUblishingHouse.Allrightsreservedhttp://www.cnki.net1 期 廖洁丹等：恩诺沙星及其代谢产物在奶牛乳中的消除规律 317 Song Z Y, Liu G T. Current Pharmacology. Beijing：Chinese Union Medical University and Beijing Medical University Unified Publishiing Company, 1994: 107-122. (in Chinese) [13] Kaartinen L, Salonen M, Älli L, Pyörälä S. Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. Journal of Veterinary Pharmacology and Therapeutics, 1995, 18(8): 357-362. [14] Kaartinen L, Pyörälä S, Moilanen M, Räisänen S. Pharmacokinetics of enrofloxacin in newborn and one-week-old calves. Journal of Veterinary Pharmacology and Therapeutics, 1997, 20: 479-482. [15] Sharma P K, Ahmad A H, Sharma L D, Varma R. Pharmacokinetics of enrofloxacin and the rate of formation of its metabolite ciprofloxacin following intravenous and intramuscular single dose administration to male buffalo calves. The Veterinary Journal, 2003, 166: 101-104. [16] Rantala M, Kaartinen L, Välimäki E, Stryrman M, Hiekkaranta M, Niemi A, Saari L, Pyörälä S. Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology and Therapeutics, 2002, 25: 251-258. [17] Papich M G, Vancamp S D, Cole J A, Whitacre M D. Pharmacokinetics and endometrial tissue concentrations of enrofloxacin and the metabolite ciprofloxacin after i.v. administration of enrofloxacin to mares. Journal of Veterinary Pharmacology and Therapeutics, 2002, 25: 343-350. [18] Bidgood T L, Papich M G. Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs. Journal of Veterinary Pharmacology and Therapeutics, 2005, 28: 329-341. [19] Cester C C, Toutain P L. A comprehensive model for enrofloxacin to ciprofloxacin transformation and disposition in the dog. Journal of Pharmacological Science, 1997, 86: 1148-1155. [20] Manceau J, Gicquel M, Laurentie M, Sanders P. Simultaneous determination of enrofloxacin and ciprofloxacin in animal biological fluids by high-performance liquid chromatography application in pharmacokinetic studies in pig and rabbit. Journal of Chromatography B, 1999, 726: 175-184. [21] Knoll U, Glunder G, Kietzmann M. Comparative study of the plasma pharmacokinetics and tissue concentrations of danofloxacin and enrofloxacin in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics, 1999, (2): 239-246. [22] Rao G S, Ramesh S, Ahmad A H, Tripathi H C, Sharma L D, Malik J K. Disposition kinetics of enrofloxacin and ciprofloxacin following intravenous administration of enrofloxacin in goats. Small Ruminant Research, 2002, 44: 9-15. [23] Rao G S, Ramesh S, Ahmad A H, Tripathi H C, Sharma L D, Malik J K. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in goats given enrofloxacin alone and in combination with Probenecid. The Veterinary Journal, 2002, 163: 85-93. [24] De Lucas J J, Rodríguez C, Martella M B, Lábaque M C, Navarro J L, San Andrés M I. Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study. Research in Veterinary Science, 2005, 78: 265-267. [25] Shem-Tov M, Rav-on O, Ziv G, Lavi E, Glickman A, Saran A. Pharmacokinetics and penetration of danofloxacin from the blood into the milk of cows. Journal of Veterinary Pharmacology and Therapeutics, 1998, 21: 209-213. [26] 卜仕金, 冯淇辉. 环丙沙星在内毒素诱导的乳房炎奶山羊药动学 及乳汁和组织浓度. 中国兽药学报, 2000, 20(3): 271-274. Pu S J, Feng Q H. Pharmacokinetics of ciprofloxacin and its concentrations in milk and udder tissues in goats with endotoxin induced mastitis. Chinese Journal of Veterinary Science, 2000, 20(3): 271-274. (in Chinese) （责任编辑 林鉴非）