Inhibitors of NF-kB Signaling Pathway 2008年诺贝尔化学奖获得者-下村脩 A Wonderful Wife Beside Him-w下r作w Pseudopterosin A 禁两分佛果的公 探索大自然的奥秘 Allelochemics他感物质 赞禁驾 热 t Ed 2 1 Inhibitors of NF-kB Signaling Pathway Signaling Pathway Panepoxydone has been shown to interfere with the NF-kB signaling pathway by inducing higher molecular weight species of IkBa. Parthenolide O OH OH O O O O Panepoxydone Osamu Shimomura Aequorea victoria Jellyfishes 水母 2008年诺贝尔化学奖获得者-下村脩 A Wonderful Wife Beside Him-地下工作者 Takedown 骇客追缉令 Pseudopterosin A Anti-inflamatory (skin care lotions) Patented by U. California 1989. Pseudopterogorgia elisabethae 假蕨素A (pseudopterosin)是一种从 软珊瑚虫体内分离出来的抗炎成分 Fenical W. Proc. Nati. Acad. Sci. USA 1986, 83: 6238. O O OH HO HO OH W. Fenical Compounds 1 and 2 were the first leaf-opening substances which were isolated from nyctinastic plants Albizza julibrissin during the day and night。 Angew. Chem. Int. Ed. 2008, 39, 1400-1414. 合欢 1 2 探索大自然的奥秘 菜园里的甘蓝和芹菜就是一对“冤家”，它们的根部都能分泌化学物 质，作为杀伤对方的“化学武器”。两者碰在一起，谁都不示弱，结果搏 斗一番，弄得两败俱伤，双双枯萎。 鼠尾草的叶子能放出大量的挥发性化学物质桉树脑(Cineole, cucalyptol) 和樟脑(Camphor)。这些物质能透过角质层，进入植物的种子和幼苗， 对周围一年生植物的发芽、生长产生毒害。距植株1-2米之内寸草不生。 Allelochemics Allelochemics 他感物质 O H CH3 3C H3C H3C CH3 H3C O