BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Current Adherent Cells Potential Monitor Effects on proton release rate 自自 Silicon FReceptor-ligand binding oxynitride Metabolic drugs/poisons LEDS General cell stress COnnell et al. 1992 Pancrazio et al. 1999 Detecting antigens using T cells and a microphysiometer MCCs 130FC4R3.9TCells MBPI-I4)M4 poptie 是m (McConnell et al. 1995 Relative advantages and disadvantages of cell-based sensors Pros o Cell-based sensors may utilize the ability of cells to respond to complex mixtures of signals in a unique o Receptors, channels, and enzymes maintained in a physiologically-relevant state by the machinery of the o May provide alternatives to animal testing in the future Lecture 20-Biosensors 4 of 8BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 20 – Biosensors 4 of 8 (McConnell et al. 1992) (Pancrazio et al. 1999) Effects on proton release rate: ¥Receptor-ligand binding ¥Metabolic drugs/poisons ¥General cell stress (McConnell et al. 1995) Detecting antigens using T cells and a microphysiometer: Relative advantages and disadvantages of cell-based sensors ƒ Pros o Cell-based sensors may utilize the ability of cells to respond to complex mixtures of signals in a unique way o Receptors, channels, and enzymes maintained in a physiologically-relevant state by the machinery of the cell o May provide alternatives to animal testing in the future