HIV entry: one receptor two co-receptors Receptor: CD4 CD4 Coreceptor Virus-Cell Binding Binding Fusion Coreceptor: CCR5/CXCR4 HIV gp41 HIV targets cD4* cells the gp120 -V3 loop major targets are CD4* t cells D4 But it can also infect Host monocytes, macrophages cell CCR5/CXCR4 dendritic cells, etc. HIV (X4) HIV(R5) c-chemokine chemokine -chemokine (CCI 3, CCI 4) CD4* target cell arget cellReceptor: CD4 Coreceptor: CCR5/CXCR4 HIV entry: one receptor, two co-receptors HIV targets CD4+ cells. The major targets are CD4+ T cells. But it can also infect monocytes, macrophages, dendritic cells, etc