Relevant lipid biophysics Determination of packing parameter(PP)of amphiphiles P determines the particle form as a result of self association of amphiphiles P-cross section of hydrophobic region cross section of hydrophilic region =Vlal V volume of the hydrophobic region a effective area per headgroup(hydrophilic region) length of the hydrophobic region Lipids Shape Organization Phase Soaps lsotropic Detergents hexagonal I Lysophospholipids ?7 Inverted cone P<1g-%s Phosphatidyl- choline serine -inositol Lamellar Sphingomyelin 是日 (Cubic) Dicetylphosphate Cylinder DODAC P~1 Bilayer Phosphatidyl- ethanolamine Phosphatidic acid Reverse Cholesterol Ao micelles hexagonal量 Cardiolipin Lipid A P>1 Trsaea Mixtures Lysophosphatidyl- chotne and 阴) Lamellar Phosphatidyl- cthanolamine P-14 Determination of packing parameter (PP) of amphiphiles P determines the particle form as a result of self association of amphiphiles P = cross section of hydrophobic region cross section of hydrophilic region V volume of the hydrophobic region a effective area per headgroup (hydrophilic region) l length of the hydrophobic region l V a Relevant lipid biophysics =V/al