2。 VEC lesion (1)TF expression (2) TFPIL: Degradation of TM/PC and HS/AT-III system (3) Fibrinolysis inhibited:tPA↓,PAL↑ ()PIt adherence and aggregation: Collagen exposure, though NO, PGI, and ADP enzyme T (5XII activation: XI+HMWK+PK(prekallirein)+XI2. VEC lesion (1) TF expression: (2) TFPI↓: Degradation of TM/PC and HS/AT-III system (3) Fibrinolysis inhibited: t-PA ↓, PAI-1↑ (4) Plt adherence and aggregation: Collagen exposure , though NO, PGI2 and ADP enzyme ↑ (5) XII activation: XII+HMWK+PK(prekallirein) +XI