Li-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer.(MIM 151623 Breast tumors .o Sarcoma, leukemia, lung cancer, and adrenal cortical carcinomaLi-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer. (MIM 151623) ❖ Breast tumors ❖ Sarcoma, leukemia, lung cancer, and adrenal cortical carcinoma