Medica, Genetics Cancer genetics
Cancer Genetics Medical Genetics
Cancer Cancer is a class of diseases caused by loss of cell cycle control. 8. In animals, cell numbers are under exquisite control Loss of this control leads to proliferation of unwanted cells .8 Cancer arises when the above situation reaches a certain degree
Cancer is a class of diseases caused by loss of cell cycle control. Cancer ❖ In animals, cell numbers are under exquisite control ❖ Loss of this control leads to proliferation of unwanted cells ❖ Cancer arises when the above situation reaches a certain degree
Cancer umor %o Cancer cells are malignant tumor (vs benign tumor) cells i all cancer cells are eventually capable of metastasis
Cancer & Tumor ❖ Cancer cells are malignant tumor (vs. benign tumor) cells ❖ All cancer cells are eventually capable of metastasis
Cancer Family Unusually large numbers of blood relatives develop certain kinds of cancers
Cancer Family Unusually large numbers of blood relatives develop certain kinds of cancers
Lynch Cancer Family syndrome Il Family g Italian family Warthin As. Heredity with reference to carcinoma. Arch Intern. Med. 1913. 12: 546-555 Hauser lJ, Weller C.VA further report on the cancer family of Warthin. Am J Cancer. 1936 27:434-449 Lynch HT, Krush AJ. Cancer family ' G revisited:1895-1970. Cancer.1971.27:1505-1511
Lynch Cancer Family Syndrome Ⅱ “Family G”: Italian family Warthin AS. Heredity with reference to carcinoma. Arch. Intern. Med. 1913. 12: 546-555 Hauser IJ, Weller C. VA further report on the cancer family of Warthin. Am. J. Cancer. 1936. 27: 434-449 Lynch HT, Krush AJ. Cancer family 'G' revisited: 1895-1970. Cancer. 1971. 27: 1505-1511
Lynch Cancer Family syndrome Il Family g Italian family MIM114400
Lynch Cancer Family Syndrome Ⅱ “Family G”: Italian family MIM 114400
Lynch Cancer Family syndrome Il Family g Italian family HNPCC: 18q11-q12 .o Adenocarcinomas of the colon Carcinoma of endometrium Gastric cancer, ovary cancer, breast cancer
Lynch Cancer Family Syndrome Ⅱ HNPCC: 18q11-q12 ❖ Adenocarcinomas of the colon “Family G”: Italian family ❖ Carcinoma of endometrium ❖ Gastric cancer, ovary cancer, breast cancer
Li-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer.(MIM 151623 Breast tumors .o Sarcoma, leukemia, lung cancer, and adrenal cortical carcinoma
Li-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer. (MIM 151623) ❖ Breast tumors ❖ Sarcoma, leukemia, lung cancer, and adrenal cortical carcinoma
Cancer Family 冷 Earlier age of onset s Multiple close relatives affected g Multiple primary tumours/bilateral di isease 8 Multiple tumours in specific cancer syndrome
Cancer Family ❖ Earlier age of onset ❖ Multiple close relatives affected ❖ Multiple primary tumours/bilateral disease ❖ Multiple tumours in specific cancer syndrome
Inherited Cancer Retinoblastoma, RB(MIM 180200 Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance
Inherited Cancer Retinoblastoma, RB (MIM 180200) Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance
