OMIM Statistics for May 5, 2004 Autosomal 14353 X-linked 857 Y-linked 48 Mitochondrial 60 15318 http://www.ncbi.nim.nih.gov/omim/mimsTats.html
OMIM Statistics for May 5, 2004 Autosomal 14353 X-linked 857 Y-linked 48 Mitochondrial 60 15318 http://www.ncbi.nlm.nih.gov/Omim/mimstats.html
Basic Conception Dominant A Recessive Homozygote Aa or aa Heterozygote-Aa Genotype &z phenotype
Basic Conception Dominant —— A Homozygote —— AA or aa Heterozygote —— Aa Genotype & Phenotype Recessive —— a
Autosomal Dominant (AD) ad diseases are those in which a single copy of a mutant gene on autosome is enough for the trait to be expressed or shown
AD diseases are those in which a single copy of a mutant gene on autosome is enough for the trait to be expressed or shown. Autosomal Dominant (AD)
Pedigree Characteristics Each affected individual has one affected parent 50% of sibs are affected. Males and females are affected with equal probability X 50% of offspring are affected Passed in a vertical fashion
Each affected individual has one affected parent 50% of sibs are affected. Males and females are affected with equal probability 50% of offspring are affected Passed in a vertical fashion Pedigree Characteristics
ypes of AD X Complete dominance X Incomplete dominance(semidominance) Codominance Irregular dominance X Delayed dominance Sex-influenced dominance
Complete dominance Incomplete dominance (semidominance) Codominance Delayed dominance Irregular dominance Sex-influenced dominance Types of AD