Medica, Genetics the basis of genetics
the Basis of Genetics Medical Genetics
Cellular basis of genetics
Cellular Basis of Genetics
Structure of Eukaryote mIcrofilament Centriole Nucleus Ribosomes endoplasmic reticulum Mitochondrion Rough endoplasmic reticulum Golgi apparatus Lysosome
Structure of Eukaryote
Chromatin chromosome Euchromatin heterochromatin Euchromatin Heterochromatin 1. Strongly condensed 2. Genetic inertia 3. Be late to replicate a. Constitutive heterochromatin b. Facultative heterochromatin
1. Strongly condensed Euchromatin & heterochromatin Euchromatin Heterochromatin Chromotin & Chromosome 2. Genetic inertia 3. Be late to replicate a. Constitutive heterochromatin b. Facultative heterochromatin
Chromatin chromosome Sex chromatin X chromatin X body Barr body
Sex chromotin X chromatin X body Barr body Chromotin & Chromosome
Chromatin chromosome Sex chromatin Lyon hypothesis(1961) 1. Inactivation of all but one x chromosome 2. Happened at an early stage of embryogenesis 3. Happened on a random basis and maintained in all descendant cells Dosage compensation
Sex chromotin Lyon hypothesis (1961) 1. Inactivation of all but one X chromosome 2. Happened at an early stage of embryogenesis 3. Happened on a random basis and maintained in all descendant cells Dosage compensation Chromotin & Chromosome
Chromatin chromosome Sex chromatin Y-chromatin
Sex chromotin Y-chromatin Chromotin & Chromosome
Sex Determining Mechanism Chromosomal mechanisms(XY &o Two sex chromosomes of different sizes, X is larger . Females are XX males are Xr g Males determine the sex of the offspring Y chromosome TDF: testis-determining factor & SRY: sex-determining region of Y chromosome
Sex Determining Mechanism Chromosomal mechanisms (XY) Y chromosome ❖ Two sex chromosomes of different sizes, X is larger ❖ TDF：testis-determining factor ❖ SRY：sex-determining region of Y chromosome ❖ Females are XX, males are XY ❖ Males determine the sex of the offspring
Molecular basis of genetics
Molecular Basis of Genetics
Structure of dna P Deoxyribose bp A T GC
bp P A T G C Structure of DNA Deoxyribose