Medica, Genetics Multifactorial disease
Multifactorial Disease Medical Genetics
Major gene &t minor gene Additive effect additive gene Polygenic inheritance Multifactorialinheritance Multifactorial traits are those which result from an interaction between multiple genes and often multiple environmental factors
Major gene & Minor gene Additive effect & Additive gene Polygenic inheritance Multifactorial inheritance Multifactorial traits are those which result from an interaction between multiple genes and often multiple environmentalfactors
Qualitative Trait Monogenic trait 120cm 165cm AA ORAa Height of pituitary dwarfism &e normal
Qualitative Trait Monogenic trait 120 cm 165 cm aa AA OR Aa Height of pituitary dwarfism & normal
Qualitative Trait Monogenic trait 0~5% 5-50 100% Aa AA PAH activity of pku carrier normal
Qualitative Trait Monogenic trait 0~5 % 45~50 % 100 % aa Aa AA PAH activity of PKU、carrier & normal
Qualitative Trait Qualitative trait; genetic traits which are present or absent. One has the trait or not
Qualitative Trait Qualitative trait: genetic traits which are present or absent. One has the trait or not
Quantitative Trait Qualitative trait Quantitative trait: genetic traits which are measurable characteristics
Quantitative Trait Qualitative trait Quantitative trait: genetic traits which are measurable characteristics
Quantitative Trait 信 100157722252627171117441 410”41I"50″51″52″5′3″54″5's″56″5T"58″5q"510"s'"60”61”62
Quantitative Trait
Quantitative Trait Qualitative trait Quantitative trait 80 Gaussian distribution 60 the bell-shaped curve 50 40 s30 20 10 130140150160170180190200 Height(cm)
130 140 150 160 170 180 190 200 Height (cm) 80 70 60 50 40 30 20 10 Variability Gaussian distribution the bell-shaped curve Quantitative Trait Qualitative trait Quantitative trait
Quantitative Trait P the tallest the shortest AABB × AABB the median AaBB AB AB′ A'B AB′ AB AABB aaBB AA'BBAA'BB AB′ AABB′AABB′AABB′AABB AB AA'BBAA'BE′ A'A'BB AABB A B AABB′AABB′AABB′AABB
P the tallest the shortest AABB A’A’B’B’ F1 the median AA’BB’ F2 AB AB’ A’B A’B’ AB AABB AABB’ AA’BB AA’BB’ AB’ AABB’ AAB’B’ AA’BB’ AA’B’B’ A’B AA’BB AA’BB’ A’A’BB A’A’BB’ A’B’ AA’BB’ AA’B’B’ A’A’BB’ A’A’B’B’ Quantitative Trait
Quantitative Trait AABB AABB AA'BB AABB AABB AA'B'B AABB AABB AAB′B
AABB AAB’B’ A’A’BB A’A’B’B’ AABB’ A’A’BB’ AA’BB AA’B’B’ AA’BB’ Quantitative Trait
