Part 1 Part 2 Part3 Part 4 Part 5 Part 6 Part 7 The New England Journal of Medicine TUBERCULOSIS ASSOCIATED WITH INFLIXIMAB A TUMOR NECROSIS FACTOR C-NEUTRALIZING AGENT 147,000 patients throughtout the world receiving infliximab all reports were received by spontaneous reporting System of FDa >70 tuberculosis 40/70(56%)extrapulmonary diseases 64/70 from countries with a low incidence of tuberculosis Before prescribing TNF-a antagonist, doctors should screen patients for latent tuberculosis infection or diseasePart 5 Part 1 11 Part 2 Part 3 Part 4 Part 6 Part 7 Ø 147,000 pa0ents throughtout the world receiving infliximab Ø all reports were received by spontaneous repor0ng System of FDA Ø 70 tuberculosis 40/70 (56%) extrapulmonary diseases 64/70 from countries with a low incidence of tuberculosis Ø Before prescribing TNF-α antagonist, doctors should screen pa0ents for latent tuberculosis infec0on or disease