Part1 Part 2 Part 3 Part 4 Part 5 Part 6 Part7 Discussion TNF-a antagonist An increased risk of tuberculosis(Tb) has been reported in patients treated with tNF-a antagonists an issue that has been highlighted in a WHo black box warning The association between TNF-a antagonists and an increased risk of TB remains uncertain atypical clinical presentation (extrapulmonary in >50%, disseminated in 25%of casesPart 5 Part 1 10 Part 2 Part 3 Part 4 Part 6 Part 7 Discussion Ø An increased risk of tuberculosis (TB) has been reported in pa0ents treated with TNF-α antagonists, an issue that has been highlighted in a WHO black box warning Ø The associa0on between TNF-α antagonists and an increased risk of TB remains uncertain. Ø atypical clinical presenta0on (extrapulmonary in > 50%, disseminated in 25% of cases )