Part1 Part 2 Part 3 Part 4 Part 5 Part 6 Part7 Discussion TNF-a antagonist Tumour necrosis factor-a(TNF-a) is a pleiotropic cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (ra) inflammatory bowel disease(iBD), ankylosing spondylitis (as) and other immune-mediated or inflammation -related diseases The most frequent serious adr was infection The most prevalent infectious disease was pneumonia and higher irs of tuberculosis and pneumocystis jiroveci pneumonia(PCpPart 5 Part 1 9 Part 2 Part 3 Part 4 Part 6 Part 7 Discussion Ø Tumour necrosis factor-α (TNF-α) is a pleiotropic cytokine that plays a central role in the pathogenesis of rheumatoid arthri0s (RA), inflammatory bowel disease (IBD), ankylosing spondyli0s (AS) and other immune-mediated or inflamma0on-related diseases. Ø The most frequent serious ADR was infec0on. Ø The most prevalent infec0ous disease was pneumonia, and higher IRs of tuberculosis and Pneumocys0s jiroveci pneumonia (PCP)