Jones-Mote Hypersensitivity Now referred to as"cutaneous basophil hypersensitivity Basophils are prominent as secondary infiltrating cells Basophilic infiltration of area under epidermis Induced by soluble (weak)antigens Transient dermal response Prominent in reactions to viral antigens,in contact reactions, skin allograft rejections,reactions to tumor cells and in some cases of hypersensitivity pneumonitis (allergic alveolitis) May be important in rejection of blood-feeding ticks on the skin surfaceJones-Mote Hypersensitivity ◼ Now referred to as “cutaneous basophil hypersensitivity” ◼ Basophils are prominent as secondary infiltrating cells. ◼ Basophilic infiltration of area under epidermis ◼ Induced by soluble (weak) antigens ◼ Transient dermal response ◼ Prominent in reactions to viral antigens, in contact reactions, skin allograft rejections, reactions to tumor cells and in some cases of hypersensitivity pneumonitis (allergic alveolitis) ◼ May be important in rejection of blood-feeding ticks on the skin surface