HLA与疾病的相关性 TABLE 7-4 SOME SIGNIFICANT ASSOCIATIONS OF HLA ALLELES WITH INCREASED RISK FOR VARIOUS DISEASES Associated HLA allele Relative risk" Ankylosing spondylitis B27 90 Goodpasture's syndrome DR2 1 Gluten-sensitive enteropathy DR3 12 Hereditary hemochromatosis A3 9 B14 A3B14 Insulin-dependent diabetes mellitus DR4/DR3 Multiple sclerosis DR2 3602050 Myasthenia gravis DR3 Narcolepsy DR2 Reactive arthritis Yersinia,Salmonella,Gonococcus) B27 Reiter's syndrome B27 Rheumatoid arthritis DR4 Sjogren's syndrome Dw3 91871065 Systemic lupus erythematosus DR3 "Relative risk is calculated by dividing the frequency of the HLA aele in the patient population by the frequency in the general population: RR-(ngIAg dlisease (Ag'/Ag)control SOURCE:SAM CD:A Comprehensiv Knowlelge Base of interul Melicine,DC Dale and DD Federman.eds..1997. Scientific American,New York.HLA与疾病的相关性