TISSUE ENGINEERING Current status No one has yet employed Tissue Engineering methods to fully regenerate any tissue that does not have the capability for spontaneous regeneration The Integra skin has no hair or glandular structures and its architecture is close to but not identical to normal dermis The carticel cartilage is not articular cartilage Experience has taught us that full regeneration may not be necessary to achieve a meaningful clinical result(e.g, pain relief, recovery of function, esthetics) How close to regeneration is good enough s many examples of bone regenerationTISSUE ENGINEERING TISSUE ENGINEERING Current Status Current Status • No one has yet employed Tissue Engineering methods No one has yet employed Tissue Engineering methods to fully regenerate any tissue that does not have the to fully regenerate any tissue that does not have the capability for spontaneous regeneration*. capability for spontaneous regeneration*. – The Integra skin has no hair or glandular structures and its The Integra skin has no hair or glandular structures and its architecture is close to but not identical to normal dermis. architecture is close to but not identical to normal dermis. – The Carticel cartilage is not articular cartilage. The Carticel cartilage is not articular cartilage. • Experience has taught us that full regeneration may Experience has taught us that full regeneration may not be necessary to achieve a meaningful clinical not be necessary to achieve a meaningful clinical result ( result (e.g., pain relief, recovery of function, esthetics) ., pain relief, recovery of function, esthetics) • How close to regeneration is good enough? How close to regeneration is good enough? * Many examples of bone regeneration * Many examples of bone regeneration