CELL-MATRIX INTERACTIONS REQUIRED FOR TISSUE ENGINEERING Connective Tissues (Musculoskeletal) Mitosis! Migration2 Synthesis3 Contract.4 Bone + Articular Cartilage Ligament/Tendon Intervertebral disc —十—十—十—十 Meniscus I Inadequate mitosis requires exogenous cells 2 Inadequate migration may require a scaffold. 3 Inadequate biosynthesis require growth factors or their genes ContractionCELL-MATRIX INTERACTIONS MATRIX INTERACTIONS REQUIRED FOR TISSUE ENGINEERING REQUIRED FOR TISSUE ENGINEERING Connective Tissues (Musculoskeletal) Mitosis1 Migration2 Synthesis3 Contract.4 + + + + + + - ? ? ? + - + ? ? Bone + Articular Cartilage - Ligament/Tendon + Intervertebral Disc ? Meniscus ? 1 Inadequate mitosis requires exogenous Inadequate mitosis requires exogenous cells. 2 Inadequate migration may require a Inadequate migration may require a scaffold scaffold. 3 Inadequate biosynthesis require Inadequate biosynthesis require growth factors growth factors or their or their genes. 4 Contraction ? Contraction ?